Bốn cho thấy một đường cong sụp đổ và tất cả những điều này đã cho một mũi tiêm thứ hai từ các nhà tài trợ đầu tiên của họ: trong hai trường hợp các tế bào màu đỏ đã bị phá hủy nhanh chóng hơn và một trong hai hình thành chống-E, hai người nhận khác, sự tồn tại của một mũi tiêm thứ hai bình thường hoặc chỉ hơi dưới nhiệt độ. | CHAPTER 10 one had already formed anti-E and another formed anti-Fya. Fourteen additional subjects all of whom were K negative were injected with K-positive blood. Four showed a collapse curve and all of these were given a second injection from their first donor in two cases the red cells were more rapidly destroyed and one of the two formed anti-E in the other two recipients the survival of a second injection was normal or only slightly subnormal. Eight out of the 14 who showed normal survival of the first lot of red cells were given a second injection one showed rapid destruction and formed anti-K. In summary collapse curves were noted following 14 out of 45 first injections of red cells and occurred on average on the sixteenth day after injection range 6-33 days . In 13 out of these 14 cases a second injection was given. Normal or only slightly subnormal survival was found in eight cases and in these no alloantibodies were found. In the remaining five red cell destruction was observed following a second injection and in three of these alloantibodies two examples of anti-E and one of anti-Fya were detected. Several other studies in humans have shown an incidence of collapse curves similar to that observed by Adner and co-workers 1963 . For example in one series the incidence was reported as 20 Brown and Smith 1958 . When further cases were added to the series the incidence of collapse curves became 15 out of 40 survival measurements in 32 subjects who had almost always received 10-20 ml of blood 5-10 ml of red cells . The diminished survival at first appeared to be related to passage of red cells through a pump oxygenator but this factor was later deemed irrelevant GS Eadie personal communication . In a series studied by ER Giblett 1956 unpublished red cells from 1- 8 ml of blood obtained from the placenta of normal infants were labelled with 51Cr and injected into normal adults. Collapse was observed in three of nine cases and none of these cells was circulating
