Các nghiên cứu tiền cứu cho thấy một sự cải thiện có ý nghĩa lâm sàng của rhytids bề mặt 6 tháng 1,63 / 4. Đối với da lỏng lẻo của các xương hàm và má, điểm cải thiện đạt 2,00 / 4 vào lúc 6 tháng. Đánh giá bệnh nhân cũng tương tự | 62 Clinical procedures in laser skin rejuvenation Fig. Partially denatured collagen after Thermage treatment as 160 microns by electron microscopy. Reproduced courtesy of Dr. Brian Zelickson and Thermage Corp. sequentially through a bipolar electrode tip with epidermal cooling. Three treatments were given at 3-week intervals to 20 patients with mild to moderate rhytids and skin laxity. Optical and RF fluences ranged from 30 to 40J cm2 and from 50 to 85 J cm3 respectively. The prospective study showed a mean clinical improvement of superficial rhytids at 6 months of 4. For skin laxity of the jowl and cheek improvement scores reached 4 at 6 months. Patient assessments were similar. Side-effects were mild. In a combined study62 of ELOS with both IPL and a diode laser Fig. overall effectiveness scores in multiple measures of photodamage was approximately 26 . NONABLATIVE TECHNOLOGIES FOR SKIN TIGHTENING From the evidence that collateral heating of the dermis while targeting vascular and pigmented lesions created new collagen and decreased wrinkles sprang the idea of bulk dermal heating. Bulk dermal heating requires relatively deep energy deposition over a period of seconds as opposed to microseconds with cooling to protect the intent of tissue tightening is to actually lift or firm tissue in a three-dimensional manner. This is not the same as stimulating collagen to fill in superficial scars or wrinkles but a deeper shift in tissue volumes leading to a remodeling of the entire soft tissue envelope a completely new aesthetic capability. Collagen fibers consist of protein chains held in a triple helix. When collagen is heated non-colavent bonds linking the protein strands together are ruptured producing an amorphous arrangement of randomly coiled As the chains rearrange fibers of the denatured collagen become shorter and thicker. Heat-induced contraction of collagen and long-term fibroblastic stimulation are is the basis for the
