Polycystic Ovary Syndrome - part 5

màn hình đột biến Singapore Trung Quốc 90% Mỹ Cauc. 90% Mỹ Cauc. Nhật Bản Nhật Bản 135 PCOS/105 Controls đột biến màn hình TDTa đột biến màn hình đột biến màn hình đột biến màn hình CCE | Table 1 Continued Gene Chromosome location Polymorphism Allele Study Design Ethnicity Sample size Findings EPHX H139R Haplotype D5S474 cce Finnish Cauc. 112 PCOS 115 controls Positive haplotype only 145 FS 5pl4 D5S623 D5S822 TDT Linkage 90 US Cauc. 90 US Cauc. 150 families 39 ASPsc Negative6 33 Positive 33 FS 5pl4 D5S474 Mutation screen Chinese 64 PCOS no mutations 146 FS 5pl4 D5S623 D5S822 Exon 6 SNP D5S474 Mutation Screen TDT Linkage 90 US Cauc. 90 US Cauc. 90 US Cauc. 19 multiplex families 324 trios 75 ASPs Negative6 147 FS 5pl4 D5S623 D5S822 cce US Cauc 85 PCOS 87 controls Negative6 137 FSHR 2p21 - Mutation Screen Japanese 15 POF 38 PCOS 3 controls Negative6 148 FSHR 2p21 2p21 Mutation cce screen FSHR 2p21 D2S1352 TDT Linkage FSHR 2p21 T307A N680S cce FSH-P Exon 3 T C Mutation cce screen GATA6 18ql hCV7490431 Mutation screen 11CV1892216 rsl941084 TDT GDF9 - Mutation screen BMP15 Mutation screen GDF9B GnRH Mutation screen GRL 5q32 Asn363Ser cce GSTM1 cce GST1 22q cce Singapore Chinese Singapore Chinese 90 US Cauc. 90 US Cauc. Japanese 16 POF 124 PCOS124 PCOS 236 controls 150 families 39 ASPsc 522 cohort Negative6 149 Negative6 149 Negative6 33 Negative6 33 Positive 150 Singapore 135 PCOS 105 Possibly Chinese Controls associated with PCOS 151 90 US Cauc. 90 US Cauc. 15 PCOS 5 controls469 families Negative6 152 Japanese 15 POF 38 PCOS 3 controls No polymorphisms 153 Japanese 15 POF 38 PCOS 3 controls 80 PCOS No polymor- phisms 153 No mutations in exons 154 US Cauc. 114 PCOS 92 controls Negative6 155 South Indian 180 PCƠ 72 controls Negative6 132 South Indian 180 PCƠ 72 controls Negative6 132 Continued Table 1 Continued Gene Chromosome location Polymorphism Allele Study Design Ethnicity Sample size Findings H6PD R453Q cce Spanish Cauc. 116 PCOS 76 controls Positive 75Ố HSD11B1 T1971G cce Racially mixed 3551 population cohort Negative6 757 HSD11B1 83557insA cce Spanish Cauc 116 PCOS 76 .