Mặc dù việc thiếu rõ ràng, các bác sĩ lâm sàng nên được nhận thức của liên kết giữa động kinh và PCOS và tương lai màn hình phụ nữ động kinh độ tuổi sinh đẻ cho các bất thường sinh sản và trao đổi chất. | 144 Legro and Winans 6. CONCLUSION Despite the lack of clarity clinicians should be aware of the link between epilepsy and PCOS and prospectively screen epileptic women of childbearing age for reproductive and metabolic abnormalities. Polycystic ovary syndrome is a multidimensional metabolic syndrome involving hyperinsulinemia glucose dysregulation hyperlipidemia and obesity as well as chronic anovulation hyperandrogenism and abnormal ovarian morphology. However the prevalence of PCOS is higher in certain subgroups such as women with epilepsy and possibly bipolar disorder. In addition studies suggest that AEDs particularly valproate may heighten a woman s risk for developing PCOS while OC use may be protective in certain instances. Further prospective studies are needed to better quantify the effects of treatment as well as the underlying disorder itself on development of the PCOS phenotype. REFERENCES 1. Sam S Dunaif A. Polycystic ovary syndrome syndrome XX Trends Endocrinol Metab 2003 14 8 365-70. 2. Legro RS Spielman R Urbanek M Driscoll D Strauss JFr Dunaif A. Phenotype and genotype in polycystic ovary syndrome. Recent Prog in Horm Res 1998 53 217-56. 3. Rotterdam ESHRE ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004 81 1 19-25. 4. Rotterdam ESHRE ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome PCOS . Hum Reprod 2004 19 1 41-7. 5. Wallace H Shorvon S Tallis R. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2 052 922 and age-specific fertility rates of women with epilepsy. Lancet 1998 352 9145 1970-3. 6. Herzog AG Coleman AE Jacobs AR et al. Interictal EEG discharges reproductive hormones and menstrual disorders in epilepsy. Ann Neurol 2003 54 5 625-37. 7. Herzog AG Friedman MN. .
