Toxicology A Case-Oriented Approach - part 4

Bệnh nhân hết hạn vào 64 giờ sau uống. Nguyên nhân cái chết được cho là thiếu ôxy não tổn thương. Câu hỏi Q1. Mà không phải là dự kiến sẽ là một dấu hiệu của nhiễm độc nicotine? a) Hypertonicity b) Co giật c) Điểm yếu d) Diaphoresis Q2. Số lượng nicotine có mặt là một điếu thuốc? | hypotension occurred 30 hours after the poisoning. The patient expired at 64 hours post-ingestion. The cause of death was believed to be anoxic brain injury. Questions Q1. Which is not expected as a sign of nicotine poisoning a Hypertonicity b Seizures c Weakness d Diaphoresis Q2. What amount of nicotine is present is a single cigarette a 20 pg b 20 mg c 500 mg d 10 nanograms Q3. What treatment should be instituted for children who ingest cigarettes a Atropine as antidote b Gastrointestinal decontamination c No intervention is needed d Ipecac Q4. What is the best substance to evaluate in urine to document smoking a Nicotine b Cotinine c Nicotine epoxide d Nicotine-T-N-oxide Answers and Discussion Q1. Answer a Due to neuromuscular blockade hypotonicity rather than hypertonicity is expected in nicotine overdose. Q2. Answer b A single cigarette has from 10 to 20 mg of nicotine compared to an average cigar that contains approximately twice as much. How can cigarettes be used so extensively if the quantity of nicotine is so near the alleged lethal amount of nicotine of 60 mg Some of the nicotine is lost in sidestream smoke and some is incinerated. Further the value of 60 mg is probably something of an underestimate. Q3. Answer b Children ingesting cigarettes are in danger of slow nicotine absorbtion. Avoid Ipecac because the child might seize from nicotine and aspirate vomitus. Other forms of gastrointestinal decontamination should be attempted. Q4. Answer b Cotinine an oxidized form of nicotine is generally measured in urine to evaluate a person s smoking status. It is better to measure cotinine than nicotine because only 5 of smoked nicotine is excreted into the urine. Further the average urinary concentration of nicotine in a 2002 by CRC Press LLC hypotension occurred 30 hours after the poisoning. The patient expired at 64 hours post-ingestion. The cause of death was believed to be anoxic brain injury. Questions Q1. Which is not expected as a sign of nicotine .

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