Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Endothelial progenitor cell biology in disease and tissue regeneration. | George et al. Journal of Hematology Oncology 2011 4 24 http content 4 1 24 JOURNAL OF HEMATOLOGY ONCOLOGY REVIEW Open Access Endothelial progenitor cell biology in disease and tissue regeneration Andrea L George Pradeep Bangalore-Prakash Shilpi Rajoria Robert Suriano Arulkumaran Shanmugam Abraham Mittelman and Raj K Tiwari Abstract Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia diabetic retinopathy and in cancer. The discovery that these cells can be mobilized from their bone marrow niche to sites of inflammation and tumor to induce neovasculogenesis has afforded a novel opportunity to understand the tissue microenvironment and specific cell-cell interactive pathways. This review provides a comprehensive up-to-date understanding of the physiological function and therapeutic utility of these cells. The emphasis is on the systemic factors that modulate their differentiation mobilization and survival and presents the challenges of its potential therapeutic clinical utility as a diagnostic and prognostic reagent. Keywords Endothelial Progenitor Cells Neovascularization Estrogen Cancer Proangiogenic proteins Inflammation Tumor Microenvironment Cluster of Differentiation Antigens Chemokines Introduction As a new decade of cancer research begins many of the same problems in investigating tumor growth and metastasis remain. Much of the difficulty is due to the heterogeneity of not only the tumor types but the cellular environment of the individual tumors themselves. All cancers though still go through specific initiation promotion and progression phases. The initiation events are varied from endogenous metabolites to exogenous insults while the tumor microenvironment in part dictates the promotion and progression phases. The unanswered questions of why some tumors remain benign while others become malignant why some only grow at their primary foci while others rapidly metastasize and why some are .
