Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI. | Halsey et al. Journal of Hematology Oncology 2011 4 42 http content 4 1 42 JOURNAL OF HEMATOLOGY ONCOLOGY RESEARCH Open Access The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI l x r I r Ix x I I I r XX Ỉ 1 2 m I x x X D I I Iz3 0 I I D I l x X rX r 3 X x x -x l x X r x l x X IX l x X X X xvx 4 c X I x x I . I I ill5 XDr X X I Px r X x x 1 Christina Halsey Georgina DUCK sue Richards raranen vargna-ixnaoeiTi Frank Hill ano Brenda Gibson Abstract Background The MRC UKALLXI trial tested the efficacy of different central nervous system CNS directed therapies in childhood acute lymphoblastic leukaemia ALL . To evaluate morbidity 555 1826 randomised children underwent prospective psychological evaluations. Full Scale verbal and performance IQs were measured at 5 months 3 years and 5 years. Scores were compared in 1 all patients n 555 versus related controls n 311 2 low-risK children presenting white cell count WCC 50 X 109 1 randomised to intrathecal methotrexate n 197 versus intrathecal and high-dose intravenous methotrexate HDM n 202 and 3 high-risk children WCC 50 X 109 l age 2 years randomised to HDM n 79 versus cranial irradiation n 77 . Results There were no significant differences in IQ scores between the treatment arms in either low- or high-risk groups. Despite similar scores at baseline results at 3 and 5 years showed a significant reduction of between and points in all three IQ scores in all patient groups compared to controls P with a higher proportion of children with IQs 80 in the patient groups 13 vs. 5 at 3 years p . Conclusion Children with ALL are at risk of CNS morbidity regardless of the mode of CNS-directed therapy. Further work needs to identify individuals at high-risk of adverse CNS outcomes. Trial registration ISRCTN ISRCTN16757172 Keywords acute lymphoblastic leukaemia IQ .
