Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study | Journal of Hematology Oncology BioMed Central Research Persistence of TEL-AMLỈ fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia a FISH study Eman Mosad 1 Hosny B Hamed1 Rania M Bakry1 Azza M Ezz-Eldin2 and Nesrine M Khalifa3 Open Access Address 1Clinical Pathology Department South Egypt Cancer Institute Assiut University Assiut Egypt 2Clinical Pathology Department Assiut University Hospital Assiut University Assiut Egypt and 3Pediatric Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Email Eman Mosad - eman_mosaad@ Hosny B Hamed - badrawyh@ Rania M Azza M Ezz-Eldin - azzam80@ Nesrine M Khalifa - nesrine_khalifa@ Corresponding author Published 17 October 2008 Received 9 September 2008 Journal of Hematology Oncology 2008 1 17 doi l756-8722-l-l7 Accepted 17 October 2008 This article is available from http content l l l7 2008 Mosad et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Objectives We have analyzed t 12 2l pl3 q22 in an attempt to evaluate the frequency and prognostic significance of TEL-AML1 fusion gene in patients with childhood CD 10 positive B-ALL by fluorescence in situ hybridization FISH . Also we have monitored the prognostic value of this gene as a minimal residual disease MRD . Methods All bone marrow samples of eighty patients diagnosed as CD 10 positive B-ALL in South Egypt Cancer Institute were evaluated by fluorescence in situ hybridization FISH for t 12 21 in newly diagnosed cases and after morphological complete remission as a minimal residual disease MRD . We determined the prognostic .
