Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Treatment of multicentric Castleman's Disease accompanying multiple myeloma with bortezomib: a case report | Journal of Hematology Oncology BioMed Central Open Access Case report Treatment of multicentric Castleman s Disease accompanying multiple myeloma with bortezomib a case report Zhen-gang Yuan Xiao-yi Dun Yong-hua Li and Jian Hou Address Department of Hematology Second Affiliated Hospital to the Second Military Medical University 415 Fengyang Rd Shanghai 200003 PR China Email Zhen-gang Yuan - yuanzg@ Xiao-yi Dun - wqfcat@ Yong-hua Li - lyhood@ Jian Hou - houjian167@ Corresponding author Published 28 April 2009 Received 10 November 2008 Journal of Hematology Oncology 2009 2 19 doi 1756-8722-2-19 Accepted 28 April 2009 This article is available from http content 2 1 19 2009 Yuan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Multicentric Castleman s disease MCD is a rare lymphoproliferative disorder of unknown etiology and characterized by various clinical manifestations and multiple organ involvement. It has been reported in association with POEMS syndrome and can progress to Kaposi s sarcoma or malignant lymphoma. The disease runs a more aggressive course and a poor prognosis. Optimal therapies have not been well established up to now. We here reported a case of rare MCD complicated with multiple myeloma who received bortezomib and achieved very good remission. To our knowledge this is the first report on MCD in the setting of multiple myeloma with good response to bortezomib. Background Multicentric Castleman s disease MCD was first described as an entity in 1978 by Gaba et al 1 . The clinical manifestations of MCD are heterogeneous and usually with multiple organ involvement. It has been reported in association with POEMS syndrome but never with MM up to
