Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:CyberKnife radiosurgery for inoperable stage IA non-small cell lung cancer: 18F-fluorodeoxyglucose positron emission tomography/computed tomography serial tumor response assessment | Vahdat et al. Journal of Hematology Oncology 2010 3 6 http content 3 1 6 JOURNAL OF HEMATOLOGY ONCOLOGY RESEARCH Open Access CyberKnife radiosurgery for inoperable stage IA non-small cell lung cancer 18F-fluorodeoxyglucose positron emission tomography computed tomography serial tumor response assessment 1 1 1 X X 1 2 2 I- 1 Saloomeh Vahdat Eric K Oermann Sean P Collins Xia Yu Malak Abedalthagafi Pedro DeBrito Simeng Suy c A I I Vr. I I I-5 r t t -X I rd I itínrm 75 I A r r -X z i6 c I I I o -X z -X z 6 c r I r A I f vt r 3 f _ 11 11 f ct r t I f .4 Shadi vouseri Constanza J Gutierrez Thomas Chang Filip Banovac Eric D Anderson Giuseppe Esposito Brian T Collins1 Abstract Objective To report serial 18F-fluorodeoxyglucose 18F-FDG positron emission tomography PET computed tomography CT tumor response following CyberKnife radiosurgery for stage IA non-small cell lung cancer NSCLC . Methods Patients with biopsy-proven inoperable stage IA NSCLC were enrolled into this IRB-approved study. Targeting was based on 3-5 gold fiducial markers implanted in or near tumors. Gross tumor volumes GTVs were contoured using lung windows margins were expanded by 5 mm to establish the planning treatment volumes PTVs . Doses ranged from 42-60 Gy in 3 equal fractions. 18F-FDG PET CT was performed prior to and at 3-6-month 9-15 months and 18-24 months following treatment. The tumor maximum standardized uptake value SUVmax was recorded for each time point. Results Twenty patients with an average maximum tumor diameter of cm were treated over a 3-year period. A mean dose of 51 Gy was delivered to the PTV in 3 to 11 days mean 7 days . The 30-Gy isodose contour extended an average of 2 cm from the GTV. At a median follow-up of 43 months the 2-year Kaplan-Meier overall survival estimate was 90 and the local control estimate was 95 . Mean tumor SUVmax before treatment was range to . During early follow-up the mean tumor SUVmax remained at range to .
