Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood: a case report | Carulli et al. Journal of Medical Case Reports 2011 5 476 http content 5 1 476 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood a case report nni illi1Alocc2nHr2 K lTỉrini2 Pl ic ianim K l C i2r ir i23 Rn mo4 Cilx TIVÌT innTỉt 3 RtiI TỉmHoloi 5 Giovdnni Cdrulli Aiessaliuia MdllHI Eugenio M Cidncid Joseph I Bruno Silvdnd ViyildU Pdold Ldmbelet Elisa Cdnnizzo1 Virginid Ottdvidno1 Sdrd Gdlimberti1 Frdncesco Cdrdcciolo1 Mdrid I Ferreri6 Elend Cidbdtti1 dnd Mdrio Petrini1 Abstract Introduction Discorddnt lymphomds dre rdre entities chdrdcterized by the simultaneous presence of two distinct types of lymphomds in different dndtomic sites. We describe d very rdre cdse of simultdneous occurrence of splenic mdntle cell lymphomd dnd mdrgindl zone lymphomd involving the bone mdrrow dnd peripheral blood. Case presentation We report the cdse of d 60-yedr-old dsymptomdtic Cducdsidn womdn in whom discorddnt lymphomds were discovered when d slight lymphocytosis dnd d conspicuous splenomegdly were observed. The different morphologicdl immunophenotypicdl dnd immunohistochemicdl fedtures found in the different pdthologic sdmples obtdined from peripheral blood bone mdrrow dnd spleen sections mdde it possible to differentidte two types of non-Hodgkin B-cell lymphomds d mdntle cell lymphomd infiltrating the spleen dnd d mdrgindl zone lymphomd involving both the bone mdrrow dnd peripheral blood. Since d simildr IgH gene redrrdngement wds found both in the bone mdrrow dnd in the spleen the hypothesis of d common origin followed by d different clondl selection of the neopldstic lymphocytes mdy be tdken into consideration. Conclusion Our cdse emphdsizes the usefulness of investigdting simultdneous specimens from different dndtomic sites from the sdme pdtient dnd the relevdnt didgnostic role of splenectomy. Introduction The
