Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Guillain-Barré syndrome after tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine: a case report | Ammar Journal of Medical Case Reports 2011 5 502 http content 5 1 502 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Guillain-Barré syndrome after tetanus toxoid reduced diphtheria toxoid and acellular pertussis vaccine a case report Hussam Ammar Abstract Introduction The association of Guillain-Barré syndrome with vaccination has been described in the literature it is infrequent and controversial. An association with swine influenza influenza hepatitis and tetanus vaccination has been documented in few case reports. Case presentation A 40-year-old Caucasian man sustained a small right temporal epidural hematoma and nondisplaced right skull fractures after a fall from a roof. He was managed conservatively a tetanus toxoid reduced diphtheria toxoid and acellular pertussis vaccine was administered and a week later he was discharged home. A few days after his discharge he experienced weakness and numbness in his legs which progressed to involve his arms. Three weeks after his initial fall he was readmitted with quadriparesis. A lumbar puncture revealed a cerebrospinal fluid protein of 790 mg dL and one white blood cell. We diagnosed Guillain-Barré syndrome. Our patient was treated with intravenous immunoglobulin. Three months later his muscle strength had improved but he continued to have tingling in his hands and feet and used a walker intermittently. Conclusion To the best of our knowledge this is the first case of Guillain-Barré syndrome to be reported in the English literature after administration of tetanus toxoid reduced diphtheria toxoid and acellular pertussis vaccine. Introduction The association of Guillain-Barré syndrome GBS with vaccination has been described but is infrequent and in many settings is controversial. A small but statistically significant elevated risk of GBS was noted among swine flu vaccinees relative to non vaccinees in 1976 1 . The influenza vaccine in the 1992 to 1994 vaccine campaign was associated .
