Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report. | Themistocleous et al. Journal of Medical Case Reports 2011 5 255 http content 5 1 255 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Malignant neuroleptic syndrome following deep brain stimulation surgery a case report 13 13 I s -. 13 2 Marios S Themistocleous 1 Efstathios J Boviatsis 1 Lampis C Stavrinou 1 Pantelis Stathis and Damianos E Sakas1 3 Abstract Background The neuroleptic malignant syndrome is an uncommon but dangerous complication characterized by hyperthermia autonomic dysfunction altered mental state hemodynamic dysregulation elevated serum creatine kinase and rigor. It is most often caused by an adverse reaction to anti-psychotic drugs or abrupt discontinuation of neuroleptic or anti-parkinsonian agents. To the best of our knowledge it has never been reported following the common practice of discontinuation of anti-parkinsonian drugs during the pre-operative preparation for deep brain stimulation surgery for Parkinson s disease. Case presentation We present the first case of neuroleptic malignant syndrome associated with discontinuation of anti-parkinsonian medication prior to deep brain stimulation surgery in a 54-year-old Caucasian man. Conclusion The characteristic neuroleptic malignant syndrome symptoms can be attributed to other more common causes associated with deep brain stimulation treatment for Parkinson s disease thus requiring a high index of clinical suspicion to timely establish the correct diagnosis. As more centers become eligible to perform deep brain stimulation neurologists and neurosurgeons alike should be aware of this potentially fatal complication. Timely activation of the deep brain stimulation system may be important in accelerating the patient s recovery. Introduction Neuroleptic malignant syndrome NMS is a rare but potentially fatal disorder with a mortality rate between 10 and 30 . It is characterized by fever severe rigidity autonomic instability and an altered level of consciousness 1
