Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Adult granulosa cell tumor associated with endometrial carcinoma: a case report. | Ukah et al. Journal of Medical Case Reports 2011 5 340 http content 5 1 340 WV journalof medical l rCASE REPORTS CASE REPORT Open Access Adult granulosa cell tumor associated with endometrial carcinoma a case report Cornelius O Ukah1 Okechukwu C Ikpeze2 George U Eleje2 and Ahizechukwu C Eke3 Abstract Introduction If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered the best estimate of the incidence of associated endometrial carcinomas is under 5 . In patients with granulosa cell tumors estrogen-dependent endometrial cancers are rarely found and most of these endometrial cancers are well-differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early. Case presentation We report the case of a 65-year-old post-menopausal Nigerian woman of the Igbo tribe with an adult granulosa cell tumor that was initially treated as endometrial carcinoma. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy after histopathologic confirmation of a well-differentiated granulosa cell tumor of the ovary and a nuclear grade 1 adenocarcinoma of the endometrium International Federation of Obstetricians and Gynecologists stage 1B . She had a good post-operative recovery and was discharged 10 days after treatment. Conclusion The association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare. A high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis. Introduction Adult granulosa cell tumors account for approximately 1 to 2 of all ovarian tumors and 95 of all granulosa cell tumors 1 . They occur more often in post-menopausal than pre-menopausal women with a peak incidence between 50 and 55 years of age. They are the most common estrogenic ovarian tumors diagnosed clinically but the precise proportion of adult granulosa cell tumors that secrete hormones
