Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy | Journal of Nanobiotechnology BioMed Central Open Access Polymeric nanoparticle-encapsulated curcumin nanocurcumin a novel strategy for human cancer therapy Savita Bisht1 Georg Feldmann1 Sheetal Soni3 Rajani Ravi2 Collins Karikar1 Amarnath Maitra3 and Anirban Maitra 1 2 Address rhe Sol Goldman Pancreatic Cancer Research Center Department of Pathology Johns Hopkins University School of Medicine Baltimore Maryland USA 2Department of Oncology Johns Hopkins University School of Medicine Baltimore Maryland USA and 3Department of Chemistry University of Delhi Delhi India Email Savita Bisht - sbisht1@ Georg Feldmann - gfeldma4@ Sheetal Soni - sheetalsoni@ Rajani Ravi - ravira@ Collins Karikar - ckarika1@ Amarnath Maitra - maitraan@ Anirban Maitra - amaitra1@ Corresponding author Published 17 April 2007 Received 20 December 2006 rr r Accepted 17 April 2007 Journal of Nanobiotechnology 2007 5 3 doi 1477-3155-5-3 This article is available from http content 5 1 3 2007 Bisht et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Curcumin a yellow polyphenol extracted from the rhizome of turmeric Curcuma longa has potent anti-cancer properties as demonstrated in a plethora of human cancer cell line and animal carcinogenesis models. Nevertheless widespread clinical application of this relatively efficacious agent in cancer and other diseases has been limited due to poor aqueous solubility and consequently minimal systemic bioavailability. Nanoparticle-based drug delivery approaches have the potential for rendering hydrophobic agents like curcumin .
