Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates | Journal of Nanobiotechnology BioMed Central Research Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates Athena M Klutz1 Zhan-Guo Gao1 John Lloyd2 Asher Shainberg3 and Kenneth A Jacobson 1 Open Access Address 1Molecular Recognition Section Laboratory of Bioorganic Chemistry National Institute of Diabetes and Digestive and Kidney Diseases Bethesda Maryland 20892 USA 2Mass Spectrometry Facility Laboratory of Bioorganic Chemistry National Institute of Diabetes and Digestive and Kidney Diseases Bethesda Maryland 20892 USA and 3Faculty of Life Sciences Bar-Ilan University Ramat Gan Israel Email Athena M Klutz - KlutzA@ Zhan-Guo Gao - ZhanguoG@ John Lloyd - lloydj@ Asher Shainberg - shaina@ Kenneth A Jacobson - kajacobs@ Corresponding author Published 23 October 2008 Received 13 August 2008 Accepted 23 October 2008 Journal of Nanobiotechnology 2008 6 12 doi I86 I477-3I55-6-I2 This article is available from http content 6 1 12 2008 Klutz et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background An approach to use multivalent dendrimer carriers for delivery of nucleoside signaling molecules to their cell surface G protein-coupled receptors GPCRs was recently introduced. Results A known adenosine receptor AR agonist was conjugated to polyamidoamine PAMAM dendrimer carriers for delivery of the intact covalent conjugate to on the cell surface. Depending on the linking moiety multivalent conjugates of the N6-chain elongated functionalized congener ADAC N6- 4- 4- 2-aminoethyl amino carbonyl methyl anilino
