Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Treatment of stasis dermatitis using aminaphtone: Collapsing glomerulopathy in sickle cell disease: a case report. | Ramidi et al. Journal of Medical Case Reports 2011 5 71 http content 5 1 71 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Collapsing glomerulopathy in sickle cell disease a case report Ganga B Ramidi1 Mohan K Kurukumbi2 Peter L Sealy1 Abstract Introduction Sickle cell disease has been associated with many renal structural and functional abnormalities. Collapsing glomerulopathy or the collapsing variant of focal segmental glomerulosclerosis is a rare clinicopathologic entity in patients with sickle cell disease that requires timely diagnosis and aggressive management. Case presentation In this case report we describe a 21-year-old African-American woman with a medical history of significant sickle cell disease and asthma. She was admitted for pain decreased urine output bilateral leg swelling and reported weight gain. During her period of hospitalisation she developed acute renal failure requiring dialysis. Further investigation revealed the collapsing variant of focal segmental glomerulosclerosis. Conclusions Although focal segmental glomerulosclerosis is a common feature of sickle cell nephropathy the collapsing variant of focal segmental glomerulosclerosis or collapsing glomerulopathy has been rarely documented. Even when other risk factors are controlled collapsing glomerulopathy has a very poor prognosis. This is a rare case of a patient with massive proteinuria presenting as acute renal failure with a very poor response to corticosteroids and a much faster rate of progression to end-stage renal disease. Introduction The renal features of sickle cell disease SCD include hematuria proteinuria tubular disturbances and chronic kidney disease 1 . Proteinuria is more commonly encountered in patients with homozygous hemoglobin SS SCD than in other hemoglobinopathies 2 . Proteinuria occurs in 20 to 30 of patients with SCD although a higher incidence has also been reported. The morphologic lesions most frequently identified in SCD
