Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The use of some nanoemulsions based on aqueous propolis and lycopene extract in the skin’s protective mechanisms against UVA radiation | Butnariu and Giuchici Journal of Nanobiotechnology 2011 9 3 http content 9 1 3 JOURNAL OF NANOBIOTECHNOLOGY RESEARCH Open Access The use of some nanoemulsions based on aqueous propolis and lycopene extract in the skin s protective mechanisms against UVA radiation Monica V Butnariu f Camelia V Giuchici2t Abstract Background The use of natural products based on aqueous extract of propolis and lycopene in the skin s protective mechanisms against UVA radiation was evaluated by means of experimental acute inflammation on rat paw edema. The aim of the present study was to evaluate the harmlessness of propolis - lycopene system through evaluation of skin level changes and anti-inflammatory action. The regenerative and protective effect of the aqueous propolis and lycopene extract is based on its richness in biologically active substances such as tocopherols flavonoids amino acids polyunsaturated fatty acids the chlorophyll pigment all substances with strong antioxidant activity that modify the oxidative stress mainly by reducing the prooxidant processes and enhancing the antioxidant ones. These substances participate in the synthesis of prostaglandins and phospholipids components of cell membrane thus enhancing skin protection mechanisms. Results The experimental systems offered a sustained release of the drug in vitro for aim eight hours. The prepared formulations aim did not reveal a deteriorating effect on tissues. They proved a better therapeutic efficiency Compared to standard suspension they provided a better therapeutic efficiency coupled with extended time interval of tested parameters 24 hours . Preliminary examination of tissues showed that the experimental formulations did not irritate. Local application of propolis and lycopene aqueous extract nanoemulsion has a high potential both regarding its efficiency the analgesic effect and therapeutic safety. Conclusions This study demonstrates that propolis and lycopene extract nanoemulsions
