Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Singlet oxygen mediated DNA degradation by copper nanoparticles: potential towards cytotoxic effect on cancer cells | Jose et al. Journal of Nanobiotechnology 2011 9 9 http content 9 1 9 JOURNAL OF NANOBIOTECHNOLOGY SHORT COMMUNICATION Open Access Singlet oxygen mediated DNA degradation by copper nanoparticles potential towards cytotoxic effect on cancer cells Gregor P Jose1 Subhankar Santra2 Swadhin K Mandal2 and Tapas K Sengupta1 Abstract The DNA degradation potential and anti-cancer activities of copper nanoparticles of 4-5 nm size are reported. A dose dependent degradation of isolated DNA molecules by copper nanoparticles through generation of singlet oxygen was observed. Singlet oxygen scavengers such as sodium azide and Tris hydroxyl methyl amino methane were able to prevent the DNA degradation action of copper nanoparticles confirming the involvement of activated oxygen species in the degradation process. Additionally it was observed that the copper nanoparticles are able to exert cytotoxic effect towards U937 and Hela cells of human histiocytic lymphoma and human cervical cancer origins respectively by inducing apoptosis. The growth characteristics of U937 and Hela cells were studied applying various concentrations of the copper nanoparticles. Findings Nanotechnology is one of the most rapidly growing disciplines with a wide range of applications especially in electronics information technology sensor development catalysis and biomedical sciences 1-5 . Nanoparticles have a specific capacity for drug loading efficient photoluminescence ability and are therefore important materials in the targeted delivery of imaging agents and anti-cancer drugs 6-9 . The extremely small size of the nanoparticles makes them to be utilized for potential target oriented delivery of nanomedicines in organs such as the brain which are normally protected by specialized barriers such as the blood-brain barrier . If these trends continue with nanomedicines humans will be continuously benefited using exceedingly improved nanomaterials with diverse properties to act at the
