Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Skin reaction to inhaled tiotropium bromide: a case report. | Incorvaia et al. Journal of Medical Case Reports 2011 5 119 http content 5 1 119 WV journalof medical l rCASE REPORTS CASE REPORT Open Access Skin reaction to inhaled tiotropium bromide a case report Cristoforo Incorvaia Nicola Fuiano Raffaella Megali and Gian Galeazzo Riario-Sforza Abstract Introduction Systemic reactions to inhaled drugs are rare. To the best of our knowledge we report the first case of generalized itching related to the use oftiotropium bromide a long acting inhaled anti-cholinergic agent commonly used to treat chronic obstructive pulmonary disease. Case presentation A 78-year-old Caucasian woman was referred to our facility for allergological evaluation. Our patient had been treated twice with tiotropium for chronic obstructive pulmonary disease and had experienced an allergic reaction with itching. We performed a double-blind placebo-controlled inhalation challenge for our patient with tiotropium and a placebo. Inhalation tests yielded positive results for tiotropium and negative results for the placebo. The results of a skin prick test with tiotropium were negative. Conclusions These findings reveal that tiotropium may elicit immediate skin allergic reactions. The negative result from the skin test suggests that such a reaction is not immunoglobulin E-mediated. Introduction Tiotropium bromide is a long-acting inhaled anti-cholinergic agent commonly used to treat chronic obstructive pulmonary disease COPD 1 . A recently published review on drug safety data obtained from 26 clinical trials involving approximately 17 000 patients reported that no difference was observed between patients treated with tiotropium bromide and those given a placebo with respect to the rates of adverse events caused by cardiac vascular nervous and lower respiratory disorders 2 . Instead adverse events caused by the anticholinergic effect of tiotropium were much more common than those due to the placebo. These adverse effects included .
