Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Granulomatous pyoderma preceding chronic recurrent multifocal osteomyelitis triggered by vaccinations in a two-year-old boy: a case report | Karaca et al. Journal of Medical Case Reports 2010 4 325 http content 4 1 325 jAg JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access Granulomatous pyoderma preceding chronic recurrent multifocal osteomyelitis triggered by vaccinations in a two-year-old boy a case report 1 1 2 1 1 Neslihan Karaca Guzide Aksu Can Ozturk Nesrin Gulez Necil Kutukculer Abstract Introduction Chronic recurrent multifocal osteomyelitis is a rare systemic aseptic inflammatory disorder that involves different sites. Pathogenesis of chronic recurrent multifocal osteomyelitis is currently unknown. Case presentation A two-year-old Caucasian boy diagnosed with chronic recurrent multifocal osteomyelitis with granulomatous pyoderma following routine vaccinations is presented for the first time in the literature. Conclusion We conclude that antigen exposures might have provoked this inflammatory condition for our case. Skin and or bone lesions following vaccinations should raise suspicion of an inflammatory response such as chronic recurrent multifocal osteomyelitis only after thorough evaluation for chronic infection autoimmune immunodeficiency or vasculitic diseases. Introduction Chronic recurrent multifocal osteomyelitis CRMO is a rare systemic noninfectious inflammatory disorder that is characterised by recurrent nonsuppurative multiple osteolytic bone lesions. It accounts for 2 to 5 of all osteomyelitis cases 1 2 . It mainly affects metaphyses of the long bones with repetitive exacerbations and spontaneous remissions and is frequently associated with a cutaneous inflammatory condition such as pustulosis palmoplantaris Sweet syndrome psoriasis and pyoderma gangrenosum 3 4 . We hereby present a case of chronic recurrent multifocal osteomyelitis initially presenting as granulomatous pyoderma following routine vaccinations. Case presentation A two-year-old Caucasian boy the first child of non-consanguineous healthy parents presented with history of recurrent .
