Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Persistent Tn polyagglutination syndrome during febrile neutropenia: a case report and review of the literature Loaiza-Bonilla et al. | PR JOURNALOF MEDICAL Ur CASE reports Persistent Tn polyagglutination syndrome during febrile neutropenia a case report and review of the literature Loaiza-Bonilla et al. 2 BioMed Central Loaiza-Bonilla et al. Journal of Medical Case Reports 2011 5 8 http content 5 1 8 14 January 2011 JOURNALOF medical LrCASE REPORTS Loaiza-Bonilla et al. Journal of Medical Case Reports 2011 5 8 http content 5 1 8 CASE REPORT Open Access Persistent Tn polyagglutination syndrome during febrile neutropenia a case report and review of the literature Arturo Loaiza-Bonilla Daniel Horowitz Sheenu Sheela Anupa Baral Gabriel Tinoco Christos Kyriakopoulos Abstract Introduction Tn polyagglutination syndrome is a rare disorder that has been reported on only a few occasions in the literature and to the best of our knowledge never before in the context of febrile neutropenia. Case presentation We report the case of a 26-year-old Caucasian woman who presented to our emergency department complaining of a persistent fever over the previous three days. She had a history of long-standing refractory pancytopenia with multi-lineage dysplasia and severe neutropenia but she had rarely experienced infection. The results of a physical examination and multiple laboratory tests were unremarkable. While investigating the possible causes of the refractory long-standing pancytopenia the possibility of a polyagglutinable state was suggested. Blood samples were sent to the laboratory for an analysis of mixed-field seed lectin agglutination assay. A serum lectin panel confirmed the final diagnosis of Tn-activation. Conclusions We should include Tn-activation in our differential whenever we encounter cases of refractory longstanding idiopathic cytopenias and inconclusive bone marrow results displaying multi-lineage dysplasia. Novel genetic techniques have recently revealed the interesting pathophysiology of this phenomenon. The recognition and inclusion of Tn
