Tham khảo luận văn - đề án 'báo cáo khoa học: "peritoneal mesothelioma in a woman who has survived for seven years: a case report"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Pillai et al. Journal of Medical Case Reports 2011 5 36 http content 5 1 36 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Peritoneal mesothelioma in a woman who has survived for seven years a case report Krishna Pillai Javed Akhter Mohammad H Pourgholami David L Morris Abstract Introduction Malignant peritoneal mesothelioma is a rare cancer with poor patient survival. Female gender has been identified as a positive prognostic factor. Recently it has been suggested that the expression of estrogen receptor b in malignant mesothelioma leads to tumor suppression and a better prognosis. Case presentation We report the case of a 48-year-old Caucasian woman who is alive and disease-free seven years after the initial diagnosis and treatment of malignant peritoneal mesothelioma. Conclusion This patient s long survival may be attributable to a combination of factors including minimal disease complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy plus the estrogen receptor b positivity of the tumor. Introduction Peritoneal mesothelioma is a rare but fatal disease the incidence is approximately one per million and peritoneal mesothelioma accounts for about 20 to 30 of all cases of mesothelioma 1 . Although asbestos has been implicated as the main carcinogen 2 3 other factors such as radiation peritonitis and SV40 have all been implicated 4 . Peritoneal mesothelioma progresses with unspecific symptoms and when presented it is commonly in the form of increased abdominal girth pain and weight loss hence diagnosis is late with a poor prognosis. A number of therapeutic regimens have been used to improve prognosis 5 and currently debulking surgery is followed by hyperthermic intraperitoneal chemotherapy HIPEC . This has led to marked improvement in patients who were once classified as preterminal 6 . The current median survival is around 10 months and relative five-year survival is in approximately 16 7 . Hence more .
