Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation. | Lutz et al. Journal of Inflammation 2010 7 27 http content 7 1 27 JOURNAL OF INFLAMMATION REVIEW Open Access Anti-inflammatory treatment strategies for ischemia reperfusion injury in transplantation Jens Lutz Klaus Thurmel and Uwe Heemann Abstract Inflammatory reactions in the graft have a pivotal influence on acute as well as long-term graft function. The main reasons for an inflammatory reaction of the graft tissue are rejection episodes infections as well as ischemia reperfusion I R injury. The latter is of particular interest as it affects every solid organ during the process of transplantation. I R injury impairs acute as well as long-term graft function and is associated with an increased number of acute rejection episodes that again affect long-term graft outcome. I R injury is the result of ATP depletion during prolonged hypoxia. Further tissue damage results from the reperfusion of the tissue after the ischemic insult. Adaptive cellular responses activate the innate immune system with its Toll-like receptors and the complement system as well as the adaptive immune system. This results in a profound inflammatory tissue reaction with immune cells infiltrating the tissue. The damage is mediated by various cytokines chemokines adhesion molecules and compounds of the extracellular matrix. The expression of these factors is regulated by specific transcription factors with NF-kB being one of the key modulators of inflammation. Strategies to prevent or treat I R injury include blockade of cytokines chemokines adhesion molecules NF-kB specific MAP kinases metalloproteinases induction of protective genes and modulation of the innate immune system. Furthermore preconditioning of the donor is an area of intense research. Here pharmacological treatment as well as new additives to conventional cold storage solutions have been analyzed together with new techniques for the perfusion of grafts or methods of normothermic storage that would avoid
