Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Increase of aqueous inflammatory factors in macular edema with branch retinal vein occlusion: a case control study. | Noma et al. Journal of Inflammation 2010 7 44 http content 7 1 44 JOURNAL OF INFLAMMATION RESEARCH Open Access Increase of aqueous inflammatory factors in macular edema with branch retinal vein occlusion a case control study 1 1 2 3 Hidetaka Noma Hideharu Funatsu Tatsuya Mimura Katsunori Shimada Abstract Background This study investigated whether soluble intercellular adhesion molecule-1 sICAM-1 has a role in the pathogenesis of macular edema associated with branch retinal vein occlusion BRVO together with vascular endothelial growth factor VEGF . Methods A retrospective case control study was performed in 22 patients with BRVO and macular edema as well as 10 patients with nonischemic ocular diseases as the control group. Retinal ischemia was evaluated by measuring the area of capillary non-perfusion with Scion Image software while the severity of macular edema was examined by optical coherence tomography. Aqueous humor samples were obtained during the performance of combined vitrectomy and cataract surgery. sICAM-1 and VEGF levels in aqueous humor and plasma specimens were determined by enzyme-linked immunosorbent assay. Results Aqueous humor levels of sICAM-1 median ng ml and VEGF median 169 pg ml were significantly elevated in BRVO patients compared with the control group median pg ml and pg ml respectively P and P respectively . The aqueous humor level of sICAM-1 was significantly correlated with that of VEGF P . In addition aqueous levels of both sICAM-1 and VEGF were correlated with the size of the nonperfused area of the retina in BRVO patients P and P respectively . Furthermore aqueous levels of sICAM-1 and VEGF were both correlated with the severity of macular edema P and P respectively . Conclusions Both sICAM-1 and VEGF may be involved in the pathogenesis of macular edema associated with BRVO. Measurement of aqueous humor sICAM-1 levels may be useful for assessment of .
