Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hypercholesterolemia and microvascular dysfunction: interventional strategies. | Stapleton et al. Journal of Inflammation 2010 7 54 http content 7 1 54 JOURNAL OF INFLAMMATION REVIEW Open Access Hypercholesterolemia and microvascular dysfunction interventional strategies Phoebe A Stapleton Adam G Goodwill Milinda E James Robert W Brock Jefferson C Frisbee Abstract Hypercholesterolemia is defined as excessively high plasma cholesterol levels and is a strong risk factor for many negative cardiovascular events. Total cholesterol levels above 200 mg dl have repeatedly been correlated as an independent risk factor for development of peripheral vascular PVD and coronary artery disease CAD and considerable attention has been directed toward evaluating mechanisms by which hypercholesterolemia may impact vascular outcomes these include both results of direct cholesterol lowering therapies and alternative interventions for improving vascular function. With specific relevance to the microcirculation it has been clearly demonstrated that evolution of hypercholesterolemia is associated with endothelial cell dysfunction a nearcomplete abrogation in vascular nitric oxide bioavailability elevated oxidant stress and the creation of a strongly pro-inflammatory condition symptoms which can culminate in profound impairments alterations to vascular reactivity. Effective interventional treatments can be challenging as certain genetic risk factors simply cannot be ignored. However some hypercholesterolemia treatment options that have become widely used including pharmaceutical therapies which can decrease circulating cholesterol by preventing either its formation in the liver or its absorption in the intestine also have pleiotropic effects with can directly improve peripheral vascular outcomes. While physical activity is known to decrease PVD CAD risk factors including obesity psychological stress impaired glycemic control and hypertension this will also increase circulating levels of high density lipoprotein and .
