Mặc dù hình ảnh thụ động cho đến nay được sử dụng để phát hiện của dopamine striatal, nó là lý thuyết có thể để phát triển các phối tử có thể phát hiện phát hành của các chất dẫn truyền thần kinh khác trong các vùng não khác | . Fischman and . Badgaiyan 397 ligands have high affinity for extrastriatal receptors and are displaced from the receptor sites by amphetamine-induced dopamine release 27 97 98 . Even though dynamic receptor imaging has so far been used only for detection of striatal dopamine it is theoretically possible to develop ligands that can detect release of other neurotransmitters in other brain areas. Such developments will go a long way in enhancing our understanding of human cognitive control. Conclusion Neurotransmitter imaging has resulted in a considerable amount of new information concerning the pathogenesis of a number of neurologic and psychiatric conditions that include schizophrenia addiction Parkinson s disease Alzheimer s disease ADHD epilepsy anxiety and affective disorders. Further the use of these techniques in the diagnoses of subclinical Alzheimer s and Parkinson s disease in asymptomatic patients can help in early diagnosis and intervention. In addition localization of epileptic foci by GABA receptor imaging has been shown to improve postsurgical clinical outcome. Neurotransmitter imaging for drug evaluation has aided in the development of new compounds that target specific receptors that are dysregulated in various disorders. Evolving molecular imaging techniques like dynamic receptor imaging offer even more exciting possibilities. These techniques can identify and localize areas of the brain where specific neurotransmitters are released during a task performance or symptom provocation. It will greatly expand our understanding of the fundamental alterations in neurochemistry in psychiatric and neurologic disorders. In addition these methods will provide empirical data that can be used to formulate novel therapeutic strategies for treatment and prevention of the disorders that are associated with altered neurotransmission. References 1. Jacobs AH Li H Winkeler A et al. PET-based molecular imaging in neuroscience. Eur J Nucl Med Mol Imaging 2003 30
