Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Cetirizine a histamine H1 receptor antagonist improves viral myocarditis. | Matsumori et al. Journal of Inflammation 2010 7 39 http content 7 1 39 JOURNAL OF INFLAMMATION RESEARCH Open Access Cetirizine a histamine H1 receptor antagonist improves viral myocarditis Akira Matsumori Kanjo Yamamoto Miho Shimada Abstract Background We showed that mast cells played a critical role in the progression of heart failure induced by pressure overload and viral myocarditis in mice. In this study we investigated the effect of cetirizine a selective H1 receptor antagonist on experimental viral myocarditis induced by encephalomyocarditis EMC virus. Methods Four-week-old inbred male DBA 2 mice were inoculated intraperitoneally with 10 plaque-forming units pfu of the EMC virus. Cetirizine was administered orally at a dose of 1 or 10 mg kg per day for the survival study and 1 mg kg for the histologic and gene expression studies beginning on the day of viral inoculation. Results Cetirizine improved survival dose dependently. Heart weight to body weight ratio was significantly decreased in mice treated with cetirizine. The area of myocardial necrosis was significantly smaller in the hearts of mice treated with cetirizine compared with controls. Gene expressions of tumor necrosis factor interleukin 6 and metalloproteinase 2 were significantly suppressed in the hearts of mice treated with cetirizine. Conclusion These results suggest that cetirizine exerts its beneficial effects on viral myocarditis by suppressing expression of pro-inflammatory cytokines genes related to cardiac remodeling in the hearts of mice. Introduction In recent years mast cells have been implicated in the pathogenesis of cardiovascular and atherosclerotic disorders. In particular we have observed that mast cells cause apoptosis of cardiac myocytes and proliferation of nonmyocytes in vitro 1 . Furthermore myocardial histamine and tryptase content and mast cell density are higher in heart failure due to idiopathic dilated or ischemic cardiomyopathy than in .
