Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. | Huang et al. Journal of Inflammation 2010 7 50 http content 7 1 50 JOURNAL OF INFLAMMATION RESEARCH Open Access TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis HIVE and HIVE-control patients Ju X Huang1f L Wang1 t Ming H Jiang2t Abstract Background TNFRSF11B computational development network construction and analysis of frontal cortex of HIV encephalitis HIVE is very useful to identify novel markers and potential targets for prognosis and therapy. Methods By integration of gene regulatory network infer GRNInfer and the database for annotation visualization and integrated discovery DAVID we identified and constructed significant molecule TNFRSF11B development network from 12 frontal cortex of HIVE-control patients and 16 HIVE in the same GEO Dataset GDS1726. Results Our result verified TNFRSF11B developmental process only in the downstream of frontal cortex of HIVEcontrol patients BST2 DGKG GAS1 PDCD4 TGFBR3 VEZF1 inhibition whereas in the upstream of frontal cortex of HIVE DGKG PDCD4 activation and downstream CFDP1 DGKG GAS1 PAX6 activation BST2 PDCD4 TGFBR3 VEZF1 inhibition . Importantly we datamined that TNFRSF11B development cluster of HIVE is involved in T-cell mediated immunity cell projection organization and cell motion only in HIVE terms without apoptosis plasma membrane and kinase activity only in HIVE-control patients terms the condition is vital to inflammation brain morphology and cognition impairment of HIVE. Our result demonstrated that common terms in both HIVE-control patients and HIVE include developmental process signal transduction negative regulation of cell proliferation RNA-binding zinc-finger cell development positive regulation of biological process and cell differentiation. Conclusions We deduced the stronger TNFRSF11B development network in HIVE consistent with our number computation. It would be necessary of the stronger TNFRSF11B development .
