Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany | Journal of Negative Results in BioMedicine BioMed Central Research Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany Qumar Parwez1 Susanne Stemmier 2 JorgT Epplen2 and Sabine Hoffjan2 Address 1 Private medical practice Gladbeck Germany and 2Department of Human Genetics Ruhr-University Bochum Germany Email Qumar Parwez - Susanne Stemmier - JorgT Epplen - Sabine Hoffjan - Corresponding author Open Access Published 13 November 2008 Received 22 January 2008 . . . J . r Accepted 13 November 2008 Journal of Negative Results in BioMedicine 2008 7 9 doi l 477-5751-7-9 This article is available from http content 7 1 9 2008 Parwez et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Atopic dermatitis AD is believed to result from complex interactions between genetic and environmental factors. A main feature of AD as well as other allergic disorders is serum and tissue eosinophilia. Human eosinophils contain high amounts of cationic granule proteins including eosinophil cationic protein ECP eosinophil-derived neurotoxin EDN eosinophil peroxidase EPO and major basic protein MBP . Recently variation in genes encoding eosinophil granule proteins has been suggested to play a role in the pathogenesis of allergic disorders. We therefore genotyped selected single nucleotide polymorphisms within the ECP EDN EPO and MBP genes in a cohort of 361 German AD patients and 325 healthy controls. Results Genotype and allele frequencies did not differ between patients and controls
