Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Failure of E. coli bacteria to induce preterm delivery in the rat | Journal of Negative Results in BioMedicine BioMed Central Open Access Failure of E. coli bacteria to induce preterm delivery in the rat Emmet Hirsch 1 2 Yana Filipovich1 and Roberto Romero3 Address Department of Obstetrics and Gynecology Northshore University HealthSystem Evanston IL USA 2Department of Obstetrics and Gynecology Feinberg School of Medicine Northwestern University Chicago IL USA and 3Perinatology Research Branch Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services Bethesda MD and Detroit MI USA Email Emmet Hirsch - ehirsch@ Yana Filipovich - yfilipovich@ Roberto Romero - prbchiefstaff@ Corresponding author Published 4 January 2009 Received 8 August 2008 Journal of Negative Results in BioMedicine 2009 8 1 doi l 477-5751-8-1 Accepted 4 January 2009 This article is available from http content 8 1 1 2009 Hirsch et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We sought to develop a model of bacterially induced preterm delivery in rats to parallel similar models in mice. Methods Female Sprague-Dawley rats on day 17 of gestation normal term 21-22 days were inoculated into the uterus with either 2 X 109 - 7 X 1010 killed E. coli organisms 1 - 4 X 108 live E. coli or sterile solution. These inoculations were made either via trans-cervical catheter or by direct intrauterine injection at laparotomy. Animals were then observed for delivery for variable periods up to term. Necropsies were performed and fetal viability was assessed. Results No rats delivered prematurely after bacterial exposure 27 animals observed for at least 48 hours and .
