Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance | Journal of Negative Results in BioMedicine BioMed Central Research Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance Sushila Jaiswal Vinita Agrawal Awadhesh Kumar Jaiswal Rakesh Pandey and Ashok Kumar Mahapatra Open Access Address Department of Pathology and Neurosurgery Sanjay Gandhi Postgraduate Institute of Medical Sciences Raebareli Road Lucknow 226014 India Email Sushila Jaiswal - sushilapath@ Vinita Agrawal - vinitaag@ Awadhesh Kumar Jaiswal - jaiswal_dr_2002@ Rakesh Pandey - rak@ Ashok Kumar Mahapatra - ashokk@ Corresponding author Published 4 November 2009 Received 14 July 2009 Journal ofNegative Results in BioMedicine 2009 8 9 doi 1477-5751-8-9 Accepted 4 November 2009 This article is available from http content 8 1 9 2009 Jaiswal et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Objective The objective was to determine the expression of estrogen and progesterone receptors in vestibular schwannomas as well as to determine predictive factors for estrogen and progesterone receptor positivity. Materials and methods The study included 100 cases of vestibular schwannomas operated from January 2006 to June 2009. The clinical details were noted from the medical case files. Formaldehyde-fixed parafiin-embedded archival vestibular schwannomas specimens were used for the immunohistochemical assessment of estrogen and progesterone receptors. Results Neither estrogen nor progesterone receptors could be detected in any of our cases by means of well known immunohistochemical method using well documented monoclonal antibodies. In the control specimens a strongly positive reaction could
