Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: No connection between the level of exposition to statins in the population and the incidence/ mortality of acute myocardial infarction: An ecological study based on Sweden’s municipalities | Nilsson et al. Journal of Negative Results in BioMedicine 2011 10 6 http content 10 1 6 r M 1 JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE RESEARCH Open Access No connection between the level of exposition to statins in the population and the incidence mortality of acute myocardial infarction An ecological study based on Sweden s municipalities Staffan Nilsson1 2 Sigvard Molstad1 3 Catarina Karlberg3 Jan-Erik Karlsson4 and Lars-Goran Persson3 Abstract Background Randomised controlled trials have shown an excellent preventive effect of statins on ischemic heart disease. Our objective was to investigate if a relation can be detected between acute myocardial infarction- AMI mortality or incidence and statin utilisation for men and women in different age-groups on a population basis. Results The utilisation rate of statins increased almost three times for both men and women between 1998 and 2002. During 1998-2000 the incidence of AMI decreased clearly for men but only slightly for women. Mortality decreased from 1998 to 2002. The change in statin utilisation from 1998 to 2000 showed no correlation to the change in AMI mortality from 2000 to 2002. Statin utilisation and AMI- incidence or mortality showed no correlations when adjusting for socio-economic deprivation antidiabetic drugs and geographic coordinates. Conclusions Despite a widespread and increasing utilisation of statins no correlation to the incidence or mortality of AMI could be detected. Other factors than increased statin treatment should be analysed especially when discussing the allocation of public resources. Keywords Myocardial infarction Incidence Antilipemic agents Sweden Population Ecological study Background The premature mortality of cardiovascular disease has been declining the last decades in Sweden as well as in many other countries. This is true regarding acute myocardial infarction AMI as well according to nation wide Swedish statistics of AMI covering the period from 1987 to .
