Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis | Scarel-Caminaga et al. Journal of Negative Results in BioMedicine 2011 10 14 http content 10 1 14 r M 1 JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE BRIEF REPORT Open Access Variation in the CXCR1 gene IL8RA is not associated with susceptibility to chronic periodontitis Raquel M Scarel-Caminaga1 Karen MC Curtis1 Rivelto Renzi1 Patricia M Sogumo1 Giovana Anovazzi1 2 Aline C Viana2 Yeon J Kim2 Silvana RP Orrico2 and Joni A Cirelli2 Abstract Background The chemokine receptor 1 CXCR-1 or IL8R-alpha is a specific receptor for the interleukin 8 IL-8 which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2 860G C of the CXCR1 gene causes a conservative amino acid substitution S276T . This single nucleotide polymorphism SNP seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. Findings Similar distribution of the allelic and genotypic frequencies were observed between the groups p . Conclusions The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population. Keywords CXCR1 chemokine cytokine genetic polymorphism periodontal disease Findings The human chemokine receptor CXCR-1 or IL8R-alpha is a specific receptor for the chemokine interleukin 8 IL-8 1 . Initially identified as a chemoattractant for neutrophils IL-8 has been demonstrated to have pro-inflammatory effects including stimulation of neutrophil degranulation 2 . Cellular activities of IL-8 are mediated by CXCR-1 and CXCR-2 IL8R-beta which maintain 78 of amino acid similarity and are encoded by two single-copy genes that are located on .
