Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts. | Journal of Inflammation BioMed Central Research Open Access Nurrl dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts Mark R Davies Christine J Harding Stephanie Raines Kurt Tolley Andrew E Parker Mark Downey-Jones and Maurice RC Needham Address Respiratory and Inflammation Research Department AstraZeneca Mereside Alderley Park Macclesfield Cheshire SK10 4TG UK Email Mark R Davies - Christine J Harding - Stephanie Raines - Kurt Tolley - Andrew E Parker - Mark Downey-Jones - Maurice RC Needham - Corresponding author Published 25 November 2005 Received 03 August 2005 Journal of Inflammation 2005 2 15 doi 1476-9255-2-15 Accepted 25 November 2005 This article is available from http content 2 1 15 2005 Davies et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Nurrl is an orphan member of the nuclear receptor superfamily these orphan receptors are a group for which a ligand has yet to be identified. Nurr1 has been shown to regulate the expression of a small number of genes as a monomeric constitutively active receptor. These Nurr1 regulated genes are primarily associated with dopamine cell maturation and survival. However previous reports have shown an increased expression of Nurr1 in the synovium of patients with rheumatoid arthritis RA suggesting a pro-inflammatory role for Nurr1 in RA. In this study we investigate the potential pro-inflammatory role of Nurr1 by monitoring Nurr1 dependent gene expression in an .
