Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Comparison of the systemic and pulmonary inflammatory response to endotoxin of neutropenic and non-neutropenic rats. | Journal of Inflammation BioMed Central Research Comparison of the systemic and pulmonary inflammatory response to endotoxin of neutropenic and non-neutropenic rats Sabrina M Heidemann 1 2 and Maria Glibetic1 2 Open Access Address Department of Pediatric Critical Care Medicine and Clinical Pharmacology Wayne State University Detroit MI USA and 2Children s Hospital of Michigan 3901 Beaubien Detroit MI 48201 USA Email Sabrina M Heidemann - sheidema@ Maria Glibetic - mglibetic@ Corresponding author Published 30 March 2007 Received 9 September 2006 Accepted 30 March 2007 Journal of Inflammation 2007 4 7 doi 1476-9255-4-7 This article is available from http content 4 1 7 2007 Heidemann and Glibetic licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Neutrophil infiltration commonly occurs in acute lung injury and may be partly responsible for the inflammatory response. However acute lung injury still occurs in the neutropenic host. The objectives of this study are to determine if inflammation and acute lung injury are worse in neutropenic versus the normal host after endotoxemia. Methods Rats were divided into four groups I control 2 neutropenic 3 endotoxemic and 4 endotoxemic and neutropenic. Tumor necrosis factor TNF -a and macrophage inflammatory protein MIP-2 were measured in the blood lung lavage and for mRNA in the lung. Arterial blood gases were measured to determine the alveolar-arterial oxygen gradient which reflects on lung injury. Results In endotoxemia the neutropenic rats had lower plasma TNF-a 116 73 vs. 202 31 pg ml and higher plasma MIP-2 1 .
