Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Demonstration of a novel technique to quantitatively assess inflammatory mediators and cells in rat knee joints. | Journal of Inflammation BioMed Central Research Open Access Demonstration of a novel technique to quantitatively assess inflammatory mediators and cells in rat knee joints Nicola J Barton 1 David A Stevens2 Jane P Hughes2 Adriano G Rossi3 Iain P Chessell2 Alison J Reeve2 and Daniel S McQueen1 Address 1Division of Neuroscience University of Edinburgh Medical College 1 George Sq Edinburgh EH8 9JZ UK 2Neurology CEDD GlaxoSmithKline R D Ltd Harlow Essex CM19 5AW UK and 3MRC Centre for Inflammation Research The Queens Medical Research Institute University of Edinburgh EH16 4TJ UK Email Nicola J Barton - David A Stevens - Jane P Hughes - Adriano G Rossi - Iain P Chessell - Alison J Reeve - Daniel S McQueen - Corresponding author Published 13 June 2007 Received 19 December 2006 Journal of Inflammation 2007 4 13 doi l476-9255-4-l3 Accepted 13 June 2007 This article is available from http content 4 l l3 2007 Barton et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The inflammation that accompanies the pain and swelling associated with osteo- and rheumatoid arthritis is mediated by complex interactions of inflammatory mediators. Cytokines play a pivotal role in orchestrating many of these processes including inflammatory cell recruitment adhesion and activation. In addition prostaglandins are secreted into the synovial cavity and are involved in perpetuation of local inflammation vasodilatation and vasoconstriction and also with bone resorption. Pre-clinical models have been developed in order to correlate to the .
