Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes. | Journal of Inflammation BioMed Central Research Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes Mark JS Miller 1 Paul Bobrowski2 Meenakshi Shukla3 Kalpana Gupta3 and Tariq M Haqqi3 Open Access Address Center for Cardiovascular Sciences Albany Medical College Albany New York USA 2Rainforest Nutritionals Inc Raleigh North Carolina USA and 3Department of Medicine Case Western Reserve University School of Medicine Cleveland Ohio USA Email Mark JS Miller - markjsm03@ Paul Bobrowski - pbobrowski@ Meenakshi Shukla - Kalpana Gupta - Tariq M Haqqi - txh5@ Corresponding author Published 14 August 2007 Received 9 February 2007 Accepted 14 August 2007 Journal of Inflammation 2007 4 16 doi 1476-9255-4-16 This article is available from http content 4 1 16 2007 Miller et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The Amazonian medicinal plant Sangre de grado Croton palanostigma has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts progrado and zangrado in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evaluated for antioxidant activity and possible chondroprotective actions. Methods Acute oral safety and toxicity was tested in rats according under OECD protocol number 420. The profile of proanthocyanidin oligomers was determined by HPLC and progrado s antioxidant activity quantified by the ORAC NORAC and HORAC assays. Human cartilage explants .
