Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro. | Journal of Inflammation BioMed Central Open Access Bioavailable constituents metabolites of pomegranate Punica granatum L preferentially inhibit COX2 activity ex vivo and IL-lbeta-induced PGE2 production in human chondrocytes in vitro Meenakshi Shukla1 Kalpana Gupta1 Zafar Rasheed 1 Khursheed A Khan2 and Tariq M Haqqi 1 3 Address division of Rheumatic Diseases Department of Medicine Case Western Reserve University 10900 Euclid Avenue Cleveland OH 44106 USA 2Department of Kulliyat Faculty of Unani Medicine Aligarh Muslim University Aligarh 202 002 India and 3Department of Pathology Microbiology Immunology School of Medicine University of South Carolina 6439 Garners Ferry Road Columbia SC 29209 USA Email Meenakshi Shukla - Kalpana Gupta - Zafar Rasheed - zafarrasheed@ Khursheed A Khan - s_mustafa_zaidi@ Tariq M Haqqi - thaqqi@ Corresponding authors Published 13 June 2008 Received 25 October 2007 Journal of Inflammation 2008 5 9 doi l476-9255-5-9 Accepted I3 June 2008 This article is available from http content 5 1 9 2008 Shukla et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Several recent studies have documented that supplementation with pomegranate fruit extract inhibits inflammatory symptoms in vivo. However the molecular basis of the observed effects has not been fully revealed. Although previous studies have documented the inhibition of nitric oxide and cyclooxygenase COX activity in vitro by plant and fruit extracts added directly into the culture medium but whether concentrations of bioactive compounds sufficient enough to exert such inhibitory effects in vivo can be achieved through
