Tham khảo luận văn - đề án 'báo cáo y học: "a novel hybrid aspirin-no-releasing compound inhibits tnfalpha release from lps-activated human monocytes and macrophages"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Journal of Inflammation BioMed Central Research A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages Catriona M Turnbull1 Paolo Marcarino2 Tara A Sheldrake4 Loretta Lazzarato2 Clara Cena2 Roberta Fruttero2 Alberto Gasco2 Sarah Fox4 Ian L Megson3 and Adriano G Rossi 4 Open Access Address 1Centre for Cardiovascular Science Queen s Medical Research Institute University of Edinburgh Edinburgh EH16 4TJ UK 2Dipartimento di Scienza e Tecnologia del Farmaco Università degli Studi di Torino Turin Italy 3Free Radical Research Facility UHI Millennium Institute Inverness IV2 3BL UK and 4MRC Centre for Inflammation Research Queen s Medical Research Institute University of Edinburgh Edinburgh EH16 4TJ UK Email Catriona M Turnbull - Paolo Marcarino - Tara A Sheldrake - Loretta Lazzarato - Clara Cena - Roberta Fruttero - Alberto Gasco - Sarah Fox - sfox1@ Ian L Megson - Adriano G Rossi - Corresponding author Published 31 July 2008 Received 6 March 2007 Journal of Inflammation 2008 5 12 doi 1476-9255-5-12 Accepted 31 July 2008 This article is available from http content 5 1 12 2008 Turnbull et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The cytoprotective nature of nitric oxide NO led to development of NO-aspirins in the hope of overcoming the gastric side-effects of aspirin. However the NO moiety gives these hybrids potential for actions further to their aspirin-mediated anti-platelet .
