Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis. | Journal of Inflammation BioMed Central Open Access CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis Yuanfan Wang1 Long Cui1 Waldemar Gonsiorek1 2 Soo-Hong Min1 Gopinadhan Anilkumar1 Stuart Rosenblum1 Joseph Kozlowski1 Daniel Lundell1 Jay S Fine1 2 and Ethan P Grant 1 Address Schering-Plough Research Institute 2015 Galloping Hill Road Kenilworth NJ 07033 USA and 2Hoffmann-La Roche Inc. 340 Kingsland St. Nutley NJ 07110 USA Email Yuanfan Wang - Long Cui - Waldemar Gonsiorek - Soo-Hong Min - Gopinadhan Anilkumar - Stuart Rosenblum - Joseph Kozlowski - Daniel Lundell - Jay S Fine - Ethan P Grant - Corresponding author Published II November 2009 Received 22 July 2009 Accepted 1 1 November 2009 Journal of Inflammation 2009 6 32 doi 1476-9255-6-32 This article is available from http content 6 1 32 2009 Wang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus of much interest as a target for inflammatory disease. Methods Here we examined the effects of CCR2 blockade with a potent small molecule antagonist to determine the pharmacodynamic consequences on the peripheral blood monocyte compartment in the context of acute and chronic inflammatory processes. Results We demonstrate that CCR2 antagonism in vivo led to a rapid decrease in
