Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock. | Nguyen et al. Journal of Inflammation 2010 7 6 http content 7 1 6 JOURNAL OF INFLAMMATION RESEARCH Open Access Early lactate clearance is associated with biomarkers of inflammation coagulation apoptosis organ dysfunction and mortality in severe sepsis and septic shock HD r Ĩ l I z-i I I r r . 5 6h ỉ r . I r L I fs fs m L 3 I f-i r I I s f k U .4 5 I r- s1 c L L 1 Dz U . k h I C h4- v 1 Bryant Nguyen Manisha Loomba James J Yang Gordon Jacobsen Kant Dhan Ronny M Otero Arturo Suarez1 Hemal Parekh6 Anja Jaehne1 Emanuel P Rivers1 2 Abstract Background Lactate clearance a surrogate for the magnitude and duration of global tissue hypoxia is used diagnostically therapeutically and prognostically. This study examined the association of early lactate clearance with selected inflammatory coagulation apoptosis response biomarkers and organ dysfunction scores in severe sepsis and septic shock. Methods Measurements of serum arterial lactate biomarkers interleukin-1 receptor antagonist interleukin-6 interleukin-8 interleukin-10 tumor necrosis factor-alpha intercellular adhesion molecule-1 high mobility group box-1 D-Dimer and caspase-3 and organ dysfunction scores Acute Physiology and Chronic Health Evaluation II Simplified Acute Physiology Score II Multiple Organ Dysfunction Score and Sequential Organ Failure Assessment were obtained in conjunction with a prospective randomized study examining early goal-directed therapy in severe sepsis and septic shock patients presenting to the emergency department ED . Lactate clearance was defined as the percent change in lactate levels after six hours from a baseline measurement in the ED. Results Two-hundred and twenty patients age - years were examined with an overall lactate clearance of - and in-hospital mortality rate of . Patients were divided into four quartiles of lactate clearance - - - and - respectively p . The mean levels of all
