Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report. | Journal of Medical Case Reports BioMed Central Open Access Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity a case report Giuseppe Lapadula1 Ilaria Izzo1 Silvia Costarelli1 Giuliana Cologni1 Luisa Bercich2 Salvatore Casari1 Marco Gambarotti2 and Carlo Torti 1 Address institute of Infectious and Tropical Diseases University of Brescia Italy and 2Service of Morbid Anatomy Spedali Civili di Brescia Italy Email Giuseppe Lapadula - Ilaria Izzo - ilaix@ Silvia Costarelli - Giuliana Cologni - Luisa Bercich - bercich@ Salvatore Casari - Marco Gambarotti - Carlo Torti - Corresponding author Published 8 May 2007 Received 15 January 2007 Journal of Medical Case Reports 2007 1 19 doi 1752-1947-1-19 Accepted 8 May 2007 This article is available from http content l l l9 2007 Lapadula et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract This report regards the case of a 43 year-old HIV-positive woman who developed an episode of serious transaminase elevation during stavudine-including antiretroviral therapy. Diagnostic assessment ruled out hepatitis virus co-infection alcohol abuse besides other possible causes of liver damage. No signs of lactic acidosis were present. Liver biopsy showed portal inflammatory infiltrate spotty necrosis vacuoles of macro- and micro-vesicular steatosis acidophil and foamy hepatocytes degeneration with organelles clumping poorly formed Mallory bodies and neutrophil granulocytes attraction satellitosis . A dramatic improvement in liver function tests
