Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Proton pump inhibitor-responsive chronic cough without acid reflux: a case report | Journal of Medical Case Reports BioMed Central Case report Open Access Proton pump inhibitor-responsive chronic cough without acid reflux a case report Kouichi Nobata and Hidetsugu Asanoi Address The Department of Internal Medicine Imizu City Hospital Imizu JapanAbstract Email Kouichi Nobata - k-nobata@ Hidetsugu Asanoi - hidetugu@ Corresponding author Published 25 August 2007 Received 9 April 2007 Journal of Medical Case Reports 2007 1 69 doi 1752-1947-1-69 Accepted 25 August 2007 This article is available from http content 1 1 69 2007 Nobata and Asanoi licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Because 24-h esophageal pH monitoring is quite invasive the diagnosis of gastroesophageal reflux disease GERD -associated cough has usually been made based merely on the clinical efficacy of treatment with proton pump inhibitor PPI . Case presentation We recently encountered two patients with PPI-responsive chronic nonproductive cough for whom switching from bronchodilators and glucocorticosteroids to PPI resulted in improvement of cough. The cough returned nearly to pre-administration level a few weeks after discontinuation of PPI. Though GERD-associated cough was suspected 24-h esophageal pH monitoring revealed that the cough rarely involved gastric acid reflux. Following reinitiation of PPI the cough disappeared again. Conclusion PPI may improve cough unrelated to gastric acid reflux. Background Gastroesophageal reflux disease GERD -associated cough is a well-known type of chronic non-productive cough 1 . Asthma postnasal drip syndrome and GERD are the three most frequently identified causes of cough in Western countries 1 . However in
