Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Vitamin C-induced hyperoxaluria causing reversible tubulointerstitial nephritis and chronic renal failure: a case report | Journal of Medical Case Reports BioMed Central Case report Open Access Vitamin C-induced hyperoxaluria causing reversible tubulointerstitial nephritis and chronic renal failure a case report Shradha Rathi1 William Kern2 and Kai Lau 3 Address department of Medicine The University of Oklahoma Health Sciences Center 1100 N. Lindsay Oklahoma City OK 73104 USA department of Pathology The University of Oklahoma Health Sciences Center 1100 N. Lindsay Oklahoma City OK 73104 USA and department of Medicine The University of Oklahoma Health Sciences Center 1100 N. Lindsay Oklahoma City OK 73104 USA Email Shradha Rathi - shradha-rathi@ William Kern - bill-kern@ Kai Lau - kai-lau@ Corresponding author Published 27 November 2007 Received 30 May 2007 Accepted 27 November 2007 Journal of Medical Case Reports 2007 1 155 doi 1752-1947-1-155 r This article is available from http content 1 1 155 2007 Rathi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Vitamin C is a precursor of oxalate and promoter of its absorption potentially causing hyperoxaluria. Malabsorption causes Calcium Ca chelation with fatty acids producing enteric hyperoxaluria. Case A 73-year-old man with both risk factors was hospitalized with serum creatinine of mg dL versus mg dL four months earlier normal mg dL . Given his oxalate-rich diet chronic diarrhea and daily 680 mg vitamin C and furosemide we postulated Ca oxalate-induced nephropathy a diagnosis confirmed by documenting hyperoxaluria and finding of diffuse intraluminal crystals and extensive interstitial fibrosis on biopsy. He was hemodialysed 6 times to remove excess oxalate. Two weeks off vitamin C his creatinine .
