Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Complicated Crohn's-like colitis, associated with Hermansky-Pudlak syndrome, treated with Infliximab: a case report and brief review of the literature | Journal of Medical Case Reports BioMed Central Open Access Case report Complicated Crohn s-like colitis associated with Hermansky-Pudlak syndrome treated with Infliximab a case report and brief review of the literature George Kouklakis1 Eleni I Efremidou 2 Michael S Papageorgiou2 Evdoxia Pavlidou2 Konstantinos J Manolas1 2 and Nikolaos Liratzopoulos2 Address 1Endoscopy Unit of University General Hospital of Alexandroupolis Democritus University of Thrace Alexandroupolis Greece and 2First Department of Surgery of University General Hospital of Alexandroupolis Democritus University of Thrace Alexandroupolis Greece Email George Kouklakis - gastro@ Eleni I Efremidou - eeffraem@ Michael S Papageorgiou - mikpapa@ Evdoxia Pavlidou - epavlidou@ Konstantinos J Manolas - kmanolas@ Nikolaos Liratzopoulos - lyratzop@ Corresponding author Published 8 December 2007 Received 6 June 2007 - . . J _. n Accepted 8 December 2007 Journal of Medical Case Reports 2007 1 176 doi l 752-1947-1-176 This article is available from http content 1 1 176 2007 Kouklakis et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Hermansky-Pudlak syndrome HPS is a rare autosomal recessive inherited disorder consisting of a triad of albinism increased bleeding tendency secondary to platelet dysfunction and systemic complications associated with ceroid depositions within the reticuloendothelial system. HPS has been associated with gastrointestinal GI complications related to chronic granulomatous colitis with pathologic features suggestive of Crohn s disease. This colitis can be severe and has been reported to be poorly responsive to medical therapies .
