Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Tumor–associated antigens identified by mRNA expression profiling as tumor rejection epitopes. | Journal of Immune Based Therapies and Vaccines Original research BioMed Central Open Access Tumor-associated antigens identified by mRNA expression profiling as tumor rejection epitopes Marie Louise Andersen1 Morten Ruhwald1 Mette Thorn1 Anders Elm Pedersen1 Susanne Mathiassen1 Soren Buus2 and Mogens H Claesson 1 Address Department of Medical Anatomy University of Copenhagen Copenhagen Denmark and 2Institute of Medical Microbiology and Immunology University of Copenhagen. Copenhagen Denmark Email Marie Louise Andersen - bodil_marielouise@ Morten Ruhwald - mruhwald@ Mette Thorn - mette_thorn@ Anders Elm Pedersen - elmpedersen@ Susanne Mathiassen - susanne@ Soren Buus - Mogens H Claesson - Corresponding author Published 29 January 2003 Received 3 November 2002 Journal of Immune Based Therapies and Vaccines 2003 1 l This article is available from http content l l l Accepted 29 January 2003 2003 Andersen et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Thirteen H-2b-binding peptides derived from six potentially overexpressed proteins in p53- -thymoma SM7 cells were studied for immunogenecity and vaccine-induced prevention of tumor growth in mice inoculated with SM7 tumor cells. Six of the peptides generated specific CTL responses after immunization but only two of these peptides RAD23_3 and RAD24_3 were capable of generating a weak vaccination-induced protection against adoptive tumor growth. SM7 inoculated mice treated with a blocking antibody against the inhibitory T cell signal transducing molecule CTLA4 appeared to delay tumor take suggesting that SM7 thymoma cells are recognized by the adaptive immune system of the host. However prophylactic vaccination with .
