Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review. | Journal of Immune Based Therapies and Vaccines BioMed Central Review Open Access Dendritic cells In the forefront of immunopathogenesis and vaccine development - A review Mansour Mohamadzadeh 1 and Ronald Luftig2 Address Department of Medicine Tulane University Health Science Center New Orleans USA and 2Department of Microbiology Immunology and Parasitology Louisiana State University New Orleans USA Email Mansour Mohamadzadeh - mzadeh@ Ronald Luftig - rlufti@ Corresponding author Published 13 January 2004 Received 03 December 2003 Journal of Immune Based Therapies and Vaccines 2004 2 1 This article is available from http content 2 l l Accepted l3 January 2004 2004 Mohamadzadeh and Luftig licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Dendritic cellls DCs comprise an essential component of the immune system. These cells as antigen presenting cells APCs to naive T cells are crucial in the initiation of antigen specific immune responses. In the past years several DC subsets have been identified in different organs which exert different effects in order to elicit adaptive immune responses. Thus identification of such DC subsets has led to a better understanding of their distribution and function in the body. In this review several key properties of the immunobiology immunopathogenesis and vaccine strategies using DCs will be discussed. Review Dendritic cellls DCs are a complex heterogeneous group of multifunctional APCs. DCs are leukocytes distributed throughout lymphoid and non-lymphoid tissues in peripheral blood and afferent lymph vessels 1 . It has been shown that DCs after activation with different stimuli achieve maturation where they express high levels of several molecules on the cell surface such as MHC class I and II accessory .
