Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: he effects of chemotherapeutics on cellular metabolism and consequent immune recognition. | Journal of Immune Based Therapies and Vaccines BioMed Central Review Open Access The effects of chemotherapeutics on cellular metabolism and consequent immune recognition M Karen Newell 1 Robert Melamede1 Elizabeth Villalobos-Menuey1 Douglas Swartzendruber2 Richard Trauger3 Robert E Camley4 and William Crisp5 Address Department of Biology University of Colorado at Colorado Springs Colorado Springs CO 80933-7150 USA 2Natural Sciences Division Seaver College Pepperdine University Malibu CA 90263 USA 3Hollis Eden Pharmaceuticals San Diego CA 92121 USA 4Department of Physics University of Colorado at Colorado Springs Colorado Ssprings CO 80933-7150 USA and 5Cancer Research Institute Arizona State University Tempe AZ 85287 USA Email M Karen Newell - mnewell@ Robert Melamede - rmelamed@ Elizabeth Villalobos-Menuey - emvillal@ Douglas Swartzendruber - Richard Trauger - rtrauger@ Robert E Camley - rcamley@ William Crisp - adcrc1@ Corresponding author Received 29 December 2003 Accepted 02 February 2004 Published 02 February 2004 Journal of Immune Based Therapies and Vaccines 2004 2 3 This article is available from http content 2 1 3 2004 Newell et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract A widely held view is that oncolytic agents induce death of tumor cells directly. In this report we review and discuss the apoptosis-inducing effects of chemotherapeutics the effects of chemotherapeutics on metabolic function and the consequent effects of metabolic function on immune recognition. Finally we propose that effective chemotherapeutic and or apoptosisinducing agents at concentrations that can be achieved physiologically do not kill tumor cells directly. Rather we suggest
