Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Antigenized antibodies expressing TCR peptides immunize against rat experimental allergic encephalomyelitis. | Journal of Immune Based Therapies and Vaccines Original research BioMed Central Open Access Antigenized antibodies expressing TCR peptides immunize against rat experimental allergic encephalomyelitis Cristina Musselli Svetlana Daverio-Zanetti and Maurizio Zanetti Address The Department of Medicine and Cancer Center University of California San Diego La Jolla CA USA Email Cristina Musselli - zanettofc@ Svetlana Daverio-Zanetti - szanetti@ Maurizio Zanetti - mzanetti@ Corresponding author Published 12 November 2004 Received 24 June 2004 .. .-J_ .m I IO IX7Z or I o o Accepted 12 November 2004 Journal of Immune Based Therapies and Vaccines 2004 2 9 doi 1476-8518-2-9 This article is available from http content 2 1 9 2004 Musselli et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Immunity against the T cell receptor TCR is considered to play a central role in the regulation of experimental allergic encephalomyelitis EAE a model system of autoimmune disease characterized by a restricted usage of TCR genes. Methods of specific vaccination against the TCR of pathogenetic T cells have included attenuated T cells and synthetic peptides from the sequence of the TCR. These approaches have led to the concept that anti-idiotypic immunity against antigenic sites of the TCR which are a key regulatory element in this disease. Methods The present study in the Lewis rat used a conventional idiotypic immunization based on antigenized antibodies expressing selected peptide sequences of the TCR 93ASSDSSNTE101 and 39DMGHGLRLIHYsYdVNsTeKG59 . Results The study demonstrates that vaccination with antigenized antibodies markedly .
